Acetic Anhydride → 4-Acetoxy-5-allyl-1,3-dihydro-6-methoxy-7-methyl-3-oxoisobenzofuran

HRID 1781562노트

반응식

HRID 1781562 반응식
[CH2:1]([C:4]1[C:5]([O:17][Si](C(C)(C)C)(C)C)=[C:6]2[C:10](=[C:11]([CH3:15])[C:12]=1[O:13][CH3:14])[CH2:9][O:8][C:7]2=[O:16])[CH:2]=[CH2:3].[C:25](OC(=O)C)(=[O:27])[CH3:26]>C(O)(=O)C>[C:25]([O:17][C:5]1[C:4]([CH2:1][CH:2]=[CH2:3])=[C:12]([O:13][CH3:14])[C:11]([CH3:15])=[C:10]2[C:6]=1[C:7](=[O:16])[O:8][CH2:9]2)(=[O:27])[CH3:26]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 100663665-Allyl-4-tert-butyldimethylsilyloxy-1,3-dihydro-6-methoxy-7-methyl-3-oxoisobenzofuran

생성물 1

HCID 190463174-Acetoxy-5-allyl-1,3-dihydro-6-methoxy-7-methyl-3-oxoisobenzofuran

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 5-allyl-4-tert-butyldimethylsilyloxy-1,3-dihydro -6-methoxy-7-methyl-3-oxoisobenzofuran [(J. W. Patterson and G. Huang, Chemical Communications, 1579 (1991)] (7.5 g) in acetic acid (95 ml) and acetic anhydride (95 ml) was refluxed for 18 hours, then cooled and poured into ice water. The solution was extracted with ethyl acetate, and the extract washed with dilute aqueous sodium bicarbonate, followed by water, then dried and evaporated. The residue was chromatographed on silica gel, eluting with 7:3 hexane:ethyl acetate, to give 4-acetoxy-5-allyl -1,3-dihydro-6-methoxy-7-methyl-3-oxoisobenzofuran, mp 101°-102° C.

후처리

  1. temperaturecooled
  2. extractionThe solution was extracted with ethyl acetate
  3. washthe extract washed with dilute aqueous sodium bicarbonate
  4. customdried
  5. customevaporated
  6. customThe residue was chromatographed on silica gel
  7. washeluting with 7:3 hexane

출처 및 근거

ORD 기록
ord-7820518b8590443d8b86b8ccf4ea84e0
출처 데이터셋
uspto-grants-1997_05
특허 번호
US05633279

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