N-(2-Acetylphenyl)acetamide → N-[2-(2-bromoacetyl)phenyl]acetamide

HRID 1782709

반응식

HRID 1782709 반응식
[Br:1]Br.[C:3]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13](=[O:15])[CH3:14])(=[O:5])[CH3:4]>C(Cl)(Cl)Cl>[C:3]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13](=[O:15])[CH2:14][Br:1])(=[O:5])[CH3:4]

참가 물질

4

반응물 2

HCID 21306N-(2-Acetylphenyl)acetamideHCID 24408Bromine

생성물 1

HCID 2749459N-[2-(2-bromoacetyl)phenyl]acetamide

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

45.0 g (0.282 mol) of dry bromine were added dropwise to a boiling solution of 50.0 g (0.282 mol) of 1-[2-(acetylamino)phenyl]ethanone in 400 ml of chloroform at room temperature. The solvent was distilled off, the residue was distributed between dichloromethane and saturated ice-cold sodium hydrogen carbonate solution. The organic phase was dried over sodium sulphate, evaporated down in vacuo, the residue was triturated with diethylether and suction filtered. After drying in vacuo 35.4 g (49% of theory) of colourless crystals were obtained, Rf=0.48 (eluant: petroleum ether/ethyl acetate 2/1 v/v).

후처리

  1. distillationThe solvent was distilled off
  2. dry with materialThe organic phase was dried over sodium sulphate
  3. customevaporated down in vacuo
  4. customthe residue was triturated with diethylether and suction
  5. filtrationfiltered
  6. customAfter drying in vacuo 35.4 g (49% of theory) of colourless crystals
  7. customwere obtained

출처 및 근거

ORD 기록
ord-926f7b0a23cc4338b77caa0fd2afa495
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07498325B2

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