Methylhydrazine → HCID 23084651, 화합물

HRID 1783300노트

반응식

HRID 1783300 반응식
[C:1]([CH:4]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)[C:5]#[N:6])(=O)[CH3:2].[CH3:14][NH:15][NH2:16]>C(O)C>[NH2:6][C:5]1[N:15]([CH3:14])[N:16]=[C:1]([CH3:2])[C:4]=1[C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1

참가 물질

4

반응물 2

HCID 6061MethylhydrazineHCID 30138862-(4-Fluorophenyl)-3-oxobutanenitrile

생성물 1

HCID 23084651HCID 23084651, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

α-Acetyl-4-fluorophenylacetonitrile (65.1 g) and methylhydrazine (30.9 mL) were dissolved in ethanol (320 mL), and the mixture was heated under reflux for 3 hrs. After the completion of the reaction, the reaction mixture was cooled to room temperature, and the solvent was evaporated. The obtained solid was collected by filtration and washed with hexane to give 5-amino-4-(4-fluorophenyl)-1,3-dimethylpyrazole (69.5 g).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hrs
  3. customAfter the completion of the reaction
  4. customthe solvent was evaporated
  5. filtrationThe obtained solid was collected by filtration
  6. washwashed with hexane

출처 및 근거

ORD 기록
ord-cddb9af07abf41b494cfeb8ed3d46cb9
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07501412B2

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