Lithium Hydroxide → 4-[5-(Phenyl)-tetrazol-2-yl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
반응식
C[O:2][C:3]([CH:5]1[CH2:9][CH:8]([N:10]2[N:14]=[N:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[N:11]2)[CH2:7][N:6]1[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[O:4].[Li+].[OH-]>CO>[C:24]([O:23][C:21]([N:6]1[CH2:7][CH:8]([N:10]2[N:14]=[N:13][C:12]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)=[N:11]2)[CH2:9][CH:5]1[C:3]([OH:4])=[O:2])=[O:22])([CH3:27])([CH3:25])[CH3:26]참가 물질
4
실험 절차
To a solution of 4-[5-(phenyl)-tetrazol-2-yl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (4) in MeOH cooled to 0 degree is LiOH, and the mixture is stirred overnight. After removal of MeOH, the residue is acidified with HCl, extracted with EA, dried and concentrated to give the corresponding 4-[5-(phenyl)-tetrazol-2-yl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (5).