Sodium Hydroxide → 4-(Isopropylamino)-2-(methylthio)pyrimidine-5-carboxylic Acid

HRID 1783554노트

반응식

HRID 1783554 반응식
[CH:1]([NH:4][C:5]1[C:10]([C:11]([O:13]CC)=[O:12])=[CH:9][N:8]=[C:7]([S:16][CH3:17])[N:6]=1)([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C.O>[CH:1]([NH:4][C:5]1[C:10]([C:11]([OH:13])=[O:12])=[CH:9][N:8]=[C:7]([S:16][CH3:17])[N:6]=1)([CH3:3])[CH3:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 10491237Ethyl 4-(Isopropylamino)-2-(methylthio)pyrimidine-5-carboxylate

생성물 1

HCID 127840854-(Isopropylamino)-2-(methylthio)pyrimidine-5-carboxylic Acid수율 90%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매2회

실험 절차

To a solution of 5.0 g (19.6 mmol) of ethyl 4-(isopropylamino)-2-(methylthio)pyrimidine-5-carboxylate in 20 mL of ethanol is added a solution of 0.8 g (20.6 mmol) of sodium hydroxide in 30 mL of water. The reaction suspension is stirred at room temperature overnight. The reaction solution is diluted with 100 mL of water and washed twice with diethyl ether. The aqueous phase is neutralized with 20.6 mL of 1N HCl. The precipitate is filtered and washed twice with water, dried under vacuum at 70° C. to give 4.0 g (90%) of the title compound: mp 202-203° C. (dec).

후처리

  1. washwashed twice with diethyl ether
  2. filtrationThe precipitate is filtered
  3. washwashed twice with water
  4. customdried under vacuum at 70° C.

출처 및 근거

ORD 기록
ord-fe62e3f1d3e445e1a47193d0675cf0e7
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07501425B1

반응 노트

불러오는 중…