1-Methylpiperazine → HCID 21106562, 화합물

HRID 1783672노트

반응식

HRID 1783672 반응식
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12]Br)=[CH:9][CH:10]=2)[C:5](=[O:14])[N:4]([CH:15]([CH3:17])[CH3:16])[N:3]=1.[CH3:18][N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>C1COCC1>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:22]3[CH2:23][CH2:24][N:19]([CH3:18])[CH2:20][CH2:21]3)=[CH:9][CH:10]=2)[C:5](=[O:14])[N:4]([CH:15]([CH3:17])[CH3:16])[N:3]=1

참가 물질

4

반응물 2

HCID 531671-MethylpiperazineHCID 211065684-Bromo-7-bromomethyl-2-isopropyl-2H-phthalazin-1-one

생성물 1

HCID 21106562HCID 21106562, 화합물수율 84%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

4-Bromo-7-bromomethyl-2-isopropyl-2H-phthalazin-1-one (0.2 g, 0.56 mmol) was dissolved in THF (1 ml), to this was added N-methyl piperazine (0.14 g, 1.4 mmol) as a solution in THF (1 ml) and the reaction mixture was stirred for 1 hour. Whereupon LC-MS indicated complete consumption of starting material, the solvent was removed under vacuum and the residue was purified by flash column chromatography (elution: 90% EtOAC, 10% MeOH) to give the title compound (0.17 g, 84% yield) as a light yellow solid.

후처리

  1. customconsumption of starting material
  2. customthe solvent was removed under vacuum
  3. customthe residue was purified by flash column chromatography (elution: 90% EtOAC, 10% MeOH)

출처 및 근거

ORD 기록
ord-ef186c37fc114633ac7ebc7c23f639f4
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07501410B2

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