[CH:1]1([CH2:4][OH:5])[CH2:3][CH2:2]1.[H-].[Na+].[Br:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([CH2:19]Br)=[CH:16][CH:17]=2)[C:12](=[O:21])[N:11]([CH:22]([CH3:24])[CH3:23])[N:10]=1>C1COCC1>[Br:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([CH2:19][O:5][CH2:4][CH:1]3[CH2:3][CH2:2]3)=[CH:16][CH:17]=2)[C:12](=[O:21])[N:11]([CH:22]([CH3:24])[CH3:23])[N:10]=1Cyclopropyl-methanol (0.05 ml, 0.67 mmol) was dissolved in THF (1 ml). To this was added NaH (60%, 0.028 g, 0.72 mmol) in a single portion. The mixture was stirred at RT for 5 min then 4-bromo-7-bromomethyl-2-isopropyl-2H-phthalazin-1-one (0.2 g, 0.56 mmol) in THF (1 ml) was added in one portion and the reaction mixture was stirred for 1 hour. Whereupon LC-MS indicated complete consumption of starting material, the solvent was removed under vacuum and the residue was purified by flash column chromatography (elution: 80% heptane, 20% EtOAc) to give the title compound (0.17 g, 87% yield) as a light yellow oil. Tr=1.80 min, m/z (ES+) (M+H)+ 351 & 353
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