Stannous Chloride → 4-Piperidinecarboxylic acid, 1-(3-amino-2-pyridinyl)-

HRID 1783752노트

반응식

HRID 1783752 반응식
[N+:1]([C:4]1[C:5]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([OH:18])=[O:17])[CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1)([O-])=O.[Sn](Cl)Cl>C(OCC)(=O)C>[NH2:1][C:4]1[C:5]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([OH:18])=[O:17])[CH2:12][CH2:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 24479Stannous ChlorideHCID 16788087HCID 16788087, 화합물

생성물 1

HCID 690784654-Piperidinecarboxylic acid, 1-(3-amino-2-pyridinyl)-

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The solution of 850 mg of 3′-nitro-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid in 40 ml of ethyl acetate was admixed with 2.3 g of tin(II) chloride and stirred at room temperature for 3 hours. The mixture was then extracted with 50 ml of water, the aqueous phase was adjusted to pH=6 using sodium dihydrogenphosphate and the product was extracted with ethyl acetate. After drying the organic phase over sodium sulfate, it was concentrated under reduced pressure.

후처리

  1. extractionThe mixture was then extracted with 50 ml of water
  2. extractionthe product was extracted with ethyl acetate
  3. dry with materialAfter drying the organic phase over sodium sulfate, it
  4. concentrationwas concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ad0cb22618c14d2a9255bd81c545f040
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07501440B2

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