Ethylorthoformate → 4-cyclopropyl-7-nitro-4H-1,2,4-benzothiadiazine 1,1-dioxide

HRID 17839

반응식

HRID 17839 반응식
[CH:1]1([NH:4][C:5]2[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=2[S:14]([NH2:17])(=[O:16])=[O:15])[CH2:3][CH2:2]1.[CH:18]([O-])([O-])OCC>>[CH:1]1([N:4]2[C:5]3[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:6]=3[S:14](=[O:16])(=[O:15])[N:17]=[CH:18]2)[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 53630039EthylorthoformateHCID 675301582-Cyclopropylamino-5-nitrobenzenesulphonamide

생성물 1

HCID 675307714-cyclopropyl-7-nitro-4H-1,2,4-benzothiadiazine 1,1-dioxide

반응 조건

온도
130 °C

실험 절차

In a round-bottom flask, a mixture of 2-cyclopropylamino-5-nitrobenzenesulphonamide (5 g), originating from the Step above, and ethyl orthoformate (50 mL) is heated in the open state at 130° C. for 3 hours. The suspension obtained is cooled on an ice bath and the insoluble material is collected by filtration, washed with ether and dried.

후처리

  1. customThe suspension obtained
  2. temperatureis cooled on an ice bath
  3. filtrationthe insoluble material is collected by filtration
  4. washwashed with ether
  5. customdried

출처 및 근거

ORD 기록
ord-d3c399511b97447abf51faf290d79fe9
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741320B2

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