(2-Bromophenyl)hydrazine → 2-[N'-(2-Bromo-phenyl)-hydrazino]-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one

HRID 1784080

반응식

HRID 1784080 반응식
Cl[C:2]1[CH:17]=[C:6]2[C:7]3[C:12]([CH2:13][CH2:14][N:5]2[C:4](=[O:18])[N:3]=1)=[CH:11][C:10]([O:15][CH3:16])=[CH:9][CH:8]=3.[Br:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[NH:26][NH2:27]>>[Br:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[NH:26][NH:27][C:2]1[CH:17]=[C:6]2[C:7]3[C:12]([CH2:13][CH2:14][N:5]2[C:4](=[O:18])[N:3]=1)=[CH:11][C:10]([O:15][CH3:16])=[CH:9][CH:8]=3

참가 물질

3

반응물 2

HCID 85583(2-Bromophenyl)hydrazineHCID 575910932-chloro-9-methoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one

생성물 1

HCID 575910992-[N'-(2-Bromo-phenyl)-hydrazino]-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one

실험 절차

The title compound was prepared from 2-chloro-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one (4) and (2-bromo-phenyl)-hydrazine as in Example 1 d. 1H-NMR (400 MHz, d6-DMSO at 60° C.) δ 9.19 (br, 1H), 7.66 (brd, 1H), 7.46 (d, 1H), 7.44 (br, 1H), 7.20 (t, 1H), 6.98-6.75 (3H), 6.71 (t, 1H), 6.23 (s, 1H), 3.94 (t, 2H), 3.82 (s, 3H) and 2.93 (t, 2H); MS (ESI) (M+H)+ 413, 415.

출처 및 근거

ORD 기록
ord-c16444c92ddc4fdfa9dee910b7189801
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07501512B2

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