Sodium Dithionite → 6-Ethoxypyrimidine-2,4,5-triamine

HRID 1784107노트

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HRID 1784107 반응식
[N:1]([C:3]1[C:4]([O:11][CH2:12][CH3:13])=[N:5][C:6]([NH2:10])=[N:7][C:8]=1[NH2:9])=O.S(S([O-])=O)([O-])=O.[Na+].[Na+]>O>[NH2:10][C:6]1[N:5]=[C:4]([O:11][CH2:12][CH3:13])[C:3]([NH2:1])=[C:8]([NH2:9])[N:7]=1

참가 물질

4

반응물 2

HCID 24489Sodium Dithionite2회HCID 2272506-Ethoxy-5-nitrosopyrimidine-2,4-diamine

생성물 1

HCID 135414226-Ethoxypyrimidine-2,4,5-triamine수율 61.1%

시약·촉매·용매 1

HCID 962Water용매

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온도
60 °C

실험 절차

To a suspension of the compound of example 3 (7.12 g, 38.9 mmoles) in water (150 ml) at 60° C. was added sodium dithionite (46.7 mmol, 8.12 g). Additional sodium dithionite was added till the pink colour completely dis-appeared and a yellow solution was formed. The solution was stirred at 60° C. for another 4 hours. Water was evaporated and the resulting residue was precipitated from a small amount of water, providing the title compound as a yellow powder (4.02 g, yield 61%). Spectral data are identical with literature data (W. Pfleiderer et al. cited supra).

후처리

  1. customa yellow solution was formed
  2. customWater was evaporated
  3. customthe resulting residue was precipitated from a small amount of water

출처 및 근거

ORD 기록
ord-0e0e8be0a02f4c19bf09fd9226c5895a
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07501513B2

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