Sodium Carbonate → 2-amino-N'-hydroxypyridine-4-carboximidamide
반응식
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.Cl.[NH2:11][OH:12].C(=O)([O-])[O-].[Na+].[Na+]>O.C(O)C>[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([NH:11][OH:12])=[NH:9])[CH:5]=[CH:4][N:3]=1참가 물질
6
실험 절차
A stirred mixture of commercially available 2-amino-4-cyano-pyridine [CAS-No. 42182-27-4] (1.0 g, 8.39 mmol), hydroxylamine hydrochloride (1.17 g, 16.8 mmol) and sodium carbonate (0.89 g, 8.39 mol) in water (8 ml) and ethanol (16 ml) was heated under reflux conditions for 3 h. The reaction mixture was evaporated, water (10 ml) was added and the mixture stirred at room temperature for 1 h. The precipitate was collected by filtration to yield the title compound (0.87 g, 68%) as an off-white solid. MS (EI) 152.0 [(M)+]; mp 188° C.
후처리
- temperaturewas heated under reflux conditions for 3 h
- customThe reaction mixture was evaporated
- additionwater (10 ml) was added
- filtrationThe precipitate was collected by filtration
출처 및 근거
- ORD 기록
- ord-23fc2512cf304762b3cda44243edf4a0
- 출처 데이터셋
- uspto-grants-2009_03
- 특허 번호
- US07504404B2
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