[[(3-Nitrophenyl)amino]carbonyl]aminoacetic acid methyl ester → 3-(3-Aminophenyl)imidazolidine-2,4-dione

HRID 1785310노트

반응식

HRID 1785310 반응식
CO[C:3](=[O:18])[CH2:4][NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-])=O)[CH:10]=1)=[O:7]>Cl.CC(C)=O>[NH2:15][C:11]1[CH:10]=[C:9]([N:8]2[C:3](=[O:18])[CH2:4][NH:5][C:6]2=[O:7])[CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 1

HCID 10934009[[(3-Nitrophenyl)amino]carbonyl]aminoacetic acid methyl ester

생성물 1

HCID 246884373-(3-Aminophenyl)imidazolidine-2,4-dione수율 85.2%

시약·촉매·용매 2

HCID 180Acetone용매HCID 313Hydrochloric Acid용매

실험 절차

A suspension of [[[(3-nitrophenyl)amino]carbonyl]aminoacetic acid methyl ester (6.9 g, 27 mmol) in 6N aqueous hydrochloride solution (40 mL) and acetone (20 mL) was stirred at reflux overnight. The resulting solution was cooled and concentrated. The resulting yellowish suspension was filtered and the filter cake was washed with water (50 mL), aqueous sodium bicarbonate solution (50 mL), and air-dried to afford the title compound (4.4 g).

후처리

  1. temperatureat reflux overnight
  2. temperatureThe resulting solution was cooled
  3. concentrationconcentrated
  4. filtrationThe resulting yellowish suspension was filtered
  5. washthe filter cake was washed with water (50 mL), aqueous sodium bicarbonate solution (50 mL)
  6. customair-dried

출처 및 근거

ORD 기록
ord-79780408d8904b6aa7c78e70c80f72ef
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504410B2

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