1-Hydroxybenzotriazole → 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride 1-hydroxybenzotriazole

HRID 1785389노트

반응식

HRID 1785389 반응식
[ClH:1].[CH3:2][N:3]([CH3:12])[CH2:4][CH2:5][CH2:6][N:7]=[C:8]=[N:9][CH2:10][CH3:11].[OH:13][N:14]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[N:16]=[N:15]1>ClCCl>[OH:13][N:14]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[N:16]=[N:15]1.[ClH:1].[CH3:12][N:3]([CH3:2])[CH2:4][CH2:5][CH2:6][N:7]=[C:8]=[N:9][CH2:10][CH3:11]

참가 물질

4

반응물 2

HCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

생성물 1

HCID 865980741-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride 1-hydroxybenzotriazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

The acid (1.2 eq.), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.2 eq.) and 1-hydroxybenzotriazole (1.2 eq.) were dissolved in 20 volumes of dichloromethane and the solution stirred for 5 min at room temperature. A solution of the amine E (1 eq.) in 10 volumes dichloromethane was added to the mixture, which was stirred at room temperature overnight. The solution was washed with saturated aqueous NaHCO3, dried over Na2SO4 and filtered. The dichloromethane was removed in vacuo to give the products which were purified with appropriate eluants as shown below.

후처리

  1. stirringwas stirred at room temperature overnight
  2. washThe solution was washed with saturated aqueous NaHCO3
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. customThe dichloromethane was removed in vacuo
  6. customto give the products which
  7. customwere purified with appropriate eluants

출처 및 근거

ORD 기록
ord-5f48bf5a11d14a35a148d2be9dc00330
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504506B2

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