Acetic Acid → 1-(3-Bromophenyl)-1-methylethylamine
반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:11]C(=O)CCl)([CH3:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.NC(N)=S.C(O)(=O)C.O>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH2:11])([CH3:9])[CH3:10])[CH:5]=[CH:6][CH:7]=1참가 물질
6
실험 절차
The mixture of N-[1-(3-bromo-phenyl)-1-methyl-ethyl]-2-chloro-acetamide (1.0 g, 3.5 mmol), thiourea (0.32 g, 4.2 mmol), acetic acid (1.5 mL) in ethanol (7 mL) was heated to reflux for 10 h and brought to room temperature. Water was added to the mixture until a precipitate was formed which was filtered. The filtrate was made basic pH 7-8 with 15% NaOH. The product was extracted with ethyl acetate and concentrated to afford a yellow solid. M+1=214.
후처리
- temperaturewas heated
- temperatureto reflux for 10 h
- custombrought to room temperature
- customwas formed which
- filtrationwas filtered
- extractionThe product was extracted with ethyl acetate
- concentrationconcentrated
- customto afford a yellow solid
출처 및 근거
- ORD 기록
- ord-c93c2c43beef47f48b7d8aba95b9eaec
- 출처 데이터셋
- uspto-grants-2009_03
- 특허 번호
- US07504403B2
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