Ethylenediamine → Imidazo(1,2-a)pyridin-5(1H)-one, 2,3-dihydro-7-phenyl-

반응식

C(O[C:4](=[O:16])[CH2:5][C:6]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[CH:7][C:8]#[N:9])C.[CH2:17](N)[CH2:18][NH2:19]>>[C:10]1([C:6]2[CH:7]=[C:8]3[NH:9][CH2:17][CH2:18][N:19]3[C:4](=[O:16])[CH:5]=2)[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

참가 물질

반응물 2

HCID 3301Ethylenediamine

HCID 540877674-Cyano-3-phenyl-but-3-enoic acid ethyl ester

생성물 1

HCID 3050276Imidazo(1,2-a)pyridin-5(1H)-one, 2,3-dihydro-7-phenyl-

반응 조건

온도: 160 °C

실험 절차

4-Cyano-3-phenyl-but-3-enoic acid ethyl ester (crude, 9.37 g, 0.043 mol), ethylenediamine (3 mL, 0.043 mol) were mixed in dichlorobenze (20 mL) and heated at 160° C. overnight. The resulting suspension was cooled to room temperature, filtered, and the filtrated cake was washed with EtOAc and finally dried to provide the title compound as a brownish yellow solid. MS m/e 213 (M+H)+.

후처리

temperatureThe resulting suspension was cooled to room temperature
filtrationfiltered
washthe filtrated cake was washed with EtOAc
customfinally dried

출처 및 근거

ORD 기록: ord-ee5713a5f957405987c2c19d732f5004
출처 데이터셋: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07504403B2

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