2,4'-Dichlorobenzophenone → (2-Chlorophenyl)(4-chlorophenyl)methanol

HRID 1785632

반응식

HRID 1785632 반응식
[Cl:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)=[O:5].[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[CH:4]([OH:5])[C:6]1[CH:7]=[CH:8][C:9]([Cl:12])=[CH:10][CH:11]=1

참가 물질

4

반응물 2

HCID 665582,4'-DichlorobenzophenoneHCID 4311764Sodium borohydride

생성물 1

HCID 247332(2-Chlorophenyl)(4-chlorophenyl)methanol수율 78%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred solution of 2,4′-dichlorobenzophenone (239 mmol) in methanol (400 mL) was added sodium borohydride (119 mmol) portionwise at 0° C. Reaction mixture was warmed to room temperature and stirred for 1 hour, then quenched with water and the methanol was removed under reduced pressure. The residue was diluted with dichloromethane (400 mL) and washed with water and brine, dried (MgSO4) and concentrated in vacuo to yield the product as an orange oil (47.1 g, 78%).

후처리

  1. customReaction mixture
  2. customquenched with water
  3. customthe methanol was removed under reduced pressure
  4. additionThe residue was diluted with dichloromethane (400 mL)
  5. washwashed with water and brine
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0a11525eb48d4e06a5e6cf67c09aa1bb
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07504522B2

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