Hydrazine hydrate (1:1) → tert-butyl N-[1-(2-aminoethyl)cyclopropyl]carbamate
반응식
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][CH2:13][C:14]1([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:16][CH2:15]1.O.NN>C(O)C>[NH2:3][CH2:12][CH2:13][C:14]1([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:22])([CH3:21])[CH3:23])[CH2:15][CH2:16]1참가 물질
4
실험 절차
To a solution of 4.57 g (13.83 mmol) of tert-butyl 1-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]cyclopropylcarbamate in 80 ml of ethanol was added 3.36 ml (69.16 mmol) of hydrazine hydrate and the resulting mixture was heated under reflux for 16 h. The mixture was filtered and washed with diethyl ether. The filtrate was evaporated to dryness to give 2.3 g of pure compound as an orange oil.
후처리
- temperaturethe resulting mixture was heated
- temperatureunder reflux for 16 h
- filtrationThe mixture was filtered
- washwashed with diethyl ether
- customThe filtrate was evaporated to dryness
출처 및 근거
- ORD 기록
- ord-176c32185fd343709c7037315fa0835c
- 출처 데이터셋
- uspto-grants-2009_03
- 특허 번호
- US07507743B2
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