Hydrazine hydrate (1:1) → 2-Cyclopropyl-2-hydroxy-acetohydrazide
반응식
C[O:2][C:3](=O)[CH:4]([CH:6]1[CH2:8][CH2:7]1)[OH:5].O.[NH2:11][NH2:12]>CO>[CH:6]1([CH:4]([OH:5])[C:3]([NH:11][NH2:12])=[O:2])[CH2:8][CH2:7]1참가 물질
4
실험 절차
As described for example 112a, (rac.)-2-cyclopropyl-2-hydroxy-acetic acid methyl ester (Newall, Christopher Earle; Foxton, Michael Walter; Hartley, Charles David; Looker, Brian Edgar. Cephalosporin antibiotics. Eur. Pat. Appl. (1985), 57 pp) in methanol was reacted with hydrazine hydrate (1.0 equivalent) at rt for 76 h. All volatiles were evaporated and the residue was triturated with hexane to afford the title compound as a white solid (yield: 69%). MS: m/e=112.2 [M−H2O]+.
후처리
- customAll volatiles were evaporated
- customthe residue was triturated with hexane
출처 및 근거
- ORD 기록
- ord-108e5e87af074ab59bf196fe349f8eac
- 출처 데이터셋
- uspto-grants-2009_03
- 특허 번호
- US07507729B2
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