Sodium Hydroxide → HCID 178493213, 화합물

HRID 1786726노트

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HRID 1786726 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:25])[F:24])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[OH-].[Na+:28]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][N:6]=[C:7]([CH2:11][S+:12]([O-:26])[C:13]2[N-:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH:23]([F:24])[F:25])=[CH:19][C:20]=3[N:21]=2)[C:8]=1[O:9][CH3:10].[Na+:28]

참가 물질

4

반응물 2

HCID 14798Sodium Hydroxide2회HCID 178493214Pantoprazole2회

생성물 1

HCID 178493213HCID 178493213, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

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온도
2 °C

실험 절차

A 100 ml round bottomed flask equipped with a magnetic stir bar was charged with acetone (50 ml). Pantoprazole (10 g, 25.7 mmol) was then added to the flask. After the pantoprazole had completely dissolved, the solution was cooled to about 2° C. Forty seven percent sodium hydroxide (aq.) equivalent to 2.4 grams of solid sodium hydroxide (60.0 mmol) was slowly added to the cooled solution. A precipitate began to form immediately. The mixture was stirred for another two hours while the flask was allowed to warm to room temperature. The precipitate was filtered and washed with acetone (20 ml) and dried at 40° C. under vacuum to yield pantoprazole sodium Form 11 (6.9 g, 65%).

후처리

  1. customA 100 ml round bottomed flask equipped with a magnetic stir bar
  2. customto form immediately
  3. temperatureto warm to room temperature
  4. filtrationThe precipitate was filtered
  5. washwashed with acetone (20 ml)
  6. customdried at 40° C. under vacuum

출처 및 근거

ORD 기록
ord-acbab0da268a4f189510e34f7728fec5
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07507829B2

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