1H-Indole-3-ethanamine, 5-methoxy-, hydrochloride (1:?) → 2-(4-Cyano-3-trifluoromethyl-phenoxy)-4-methyl-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide

HRID 1786835노트

반응식

[C:1]([C:3]1[CH:17]=[CH:16][C:6]([O:7][CH:8]([CH2:12][CH:13]([CH3:15])[CH3:14])[C:9]([OH:11])=O)=[CH:5][C:4]=1[C:18]([F:21])([F:20])[F:19])#[N:2].ON1C2C=CC=CC=2N=N1.C1C=CC2N(O)N=NC=2C=1.CN(C)CCCN=C=NCC.CCN=C=NCCCN(C)C.Cl.CN1CCOCC1.Cl.[CH3:73][O:74][C:75]1[CH:86]=[C:85]2[C:78]([NH:79][CH:80]=[C:81]2[CH2:82][CH2:83][NH2:84])=[CH:77][CH:76]=1>CN(C=O)C>[CH3:73][O:74][C:75]1[CH:86]=[C:85]2[C:78](=[CH:77][CH:76]=1)[NH:79][CH:80]=[C:81]2[CH2:82][CH2:83][NH:84][C:9](=[O:11])[CH:8]([O:7][C:6]1[CH:16]=[CH:17][C:3]([C:1]#[N:2])=[C:4]([C:18]([F:21])([F:20])[F:19])[CH:5]=1)[CH2:12][CH:13]([CH3:15])[CH3:14]

참가 물질

실험 절차

The compound was prepared in the following manner. To 0.25 gm (0.83 mmol) of 2-(4-cyano-3-trifluoromethyl-phenoxy)-4-methyl-pentanoic acid in dimethylformamdie “DMF” (15 mL) were added 0.14 gm (1.04 mmol) of 1-Hydroxy-benzotriazole HOBT, 0.2 gm (1.04 mmol) of (3-(dimethylamino)propyl)ethylcarbodiimide EDCl, 0.23 gm (2.28 mmol) N-methyl morpholine, and approximately 234 mg of 5-methoxytryptamine hydrochloride (1.04 mmol). The resultant mixtures were stirred at room temperature for approximately 18 hours. The reactions were quenched with sodium bicarbonate (20 mL) and extracted with ethyl acetate (3 times 20 mL). The solvent was removed in vacuo to obtain oils that were then purified by HPLC.

후처리

customThe compound was prepared in the following manner
customThe reactions were quenched with sodium bicarbonate (20 mL)
extractionextracted with ethyl acetate (3 times 20 mL)
customThe solvent was removed in vacuo
customto obtain oils that
customwere then purified by HPLC

출처 및 근거

ORD 기록: ord-3169ad53d41a41a3a8c9ea8043dc34d8
출처 데이터셋: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07507860B2

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참가 물질

반응물 5

생성물 1

시약·촉매·용매 1

실험 절차

후처리

출처 및 근거

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