1-Amino-2-propanol → HCID 12384307, 화합물

HRID 1787861노트

반응식

HRID 1787861 반응식
[NH2:1][CH2:2][CH:3]([OH:5])[CH3:4].[C:6]1(=O)[O:11][C:9](=[O:10])[C:8]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:7]12.C(N(CC)CC)C.C1(C)C=CC=CC=1>O>[CH2:6]([O:11][C:9]([NH:1][CH2:2][CH:3]([OH:5])[CH3:4])=[O:10])[C:7]1[CH:8]=[CH:12][CH:13]=[CH:14][CH:15]=1

참가 물질

6

반응물 4

HCID 41-Amino-2-propanolHCID 1140TolueneHCID 6811Phthalic AnhydrideHCID 8471Triethylamine

생성물 1

HCID 12384307HCID 12384307, 화합물수율 142.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a round bottom flask equipped with Dean-Stark trap was added (1) (2 g, 7.4 mmol), phthalic anhydride (1.1 g, 7.4 mmol), triethylamine (0.1 mL) and toluene (50 mL). The reaction mixture was heated to reflux and water produced was collected. After refluxing for 2 hours, the solvent was removed. The residue was acidified using 1 N HCl, filtered and washed with water, dried to give 2.2 g of (2). 1H NMR (DMSO-d6, 400 MHz): δ 7.8 (m, 4H), 7.3 (m, 5H), 7.1 (d, 2H), 6.8 (d, 2H), 5.05 (m, 1H), 3.3 (m, 2H).

후처리

  1. customTo a round bottom flask equipped with Dean-Stark trap
  2. temperatureThe reaction mixture was heated
  3. temperatureto reflux
  4. customwas collected
  5. temperatureAfter refluxing for 2 hours
  6. customthe solvent was removed
  7. filtrationfiltered
  8. washwashed with water
  9. customdried

출처 및 근거

ORD 기록
ord-2b99da6e97b8436a8959456d82cfddc4
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511063B2

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