Triethylamine → 1,3-Benzodioxole, 5-(chloromethyl)-

HRID 17879

반응식

HRID 17879 반응식
[CH2:1](O)[C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1.C(N(CC)CC)C.S(Cl)([Cl:21])=O>C1C=CC=CC=1>[Cl:21][CH2:1][C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 10322Piperonyl alcoholHCID 24386Thionyl Chloride

생성물 1

HCID 887131,3-Benzodioxole, 5-(chloromethyl)-수율 100%

시약·촉매·용매 1

HCID 241Benzene용매

반응 조건

온도
0 °C

실험 절차

Piperonyl alcohol (10 g, 65.7 mmol) was dissolved in benzene. Triethylamine (11 ml, 78.8 mmol) and thionyl chloride (11 ml, 131.4 mmol) were added dropwise thereto and was stirred for 24 hours at 0° C. The reaction mixture was extracted with sodium bicarbonate and ethyl acetate, the organic layer was separated, and dried over anhydrous magnesium sulfate to obtain 5-chloromethyl benzo[1,3]dioxol (11.2 g, yield 100%).

후처리

  1. extractionThe reaction mixture was extracted with sodium bicarbonate and ethyl acetate
  2. customthe organic layer was separated
  3. dry with materialdried over anhydrous magnesium sulfate

출처 및 근거

ORD 기록
ord-d083df6e630e4365a26adb042fc2f702
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741323B2

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