Water → Ethyl 4-(cyclohexylamino)-3-nitrobenzoate

HRID 1788404

반응식

HRID 1788404 반응식
[CH2:1]([O:3][C:4](=[O:15])[C:5]1[CH:10]=[CH:9][C:8](Cl)=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)[CH3:2].[CH:16]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1.O>C(#N)C>[CH2:1]([O:3][C:4](=[O:15])[C:5]1[CH:10]=[CH:9][C:8]([NH:22][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[C:7]([N+:12]([O-:14])=[O:13])[CH:6]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 7965CyclohexylamineHCID 1268247Ethyl 4-chloro-3-nitrobenzoate

생성물 1

HCID 5298559Ethyl 4-(cyclohexylamino)-3-nitrobenzoate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of Compound 9 (22.96 g, 100 mmol), cyclohexylamine (15.31 g, 154 mmol) and TEA (13.57 g, 134 mmol) in 100 mL acetonitrile was refluxed overnight. The reaction mixture was poured into icy water and the precipitated crystals were collected by means of filtration, washed three times with water then was dried over phosphorous pentoxide in high vacuum to yield Compound 10.

후처리

  1. filtrationthe precipitated crystals were collected by means of filtration
  2. washwashed three times with water
  3. dry with materialthen was dried over phosphorous pentoxide in high vacuum

출처 및 근거

ORD 기록
ord-f5e0bd8ff69a4e21abafde0eae58e9a5
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511145B2

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