Cyclopentyl 2-(2,3-dichlorophenylmethylene)-3-oxobutanoate → 5-Cyclopentyl 3-methyl 4-(2,3-dichlorophenyl)-2-(fluoromethyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

HRID 1789016노트

반응식

HRID 1789016 반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]=[C:10]([C:19](=O)[CH3:20])[C:11]([O:13][CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:12].[NH2:22][C:23]([CH2:29][F:30])=[CH:24][C:25]([O:27][CH3:28])=[O:26]>C(O)(C)(C)C>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]1[C:10]([C:11]([O:13][CH:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[O:12])=[C:19]([CH3:20])[NH:22][C:23]([CH2:29][F:30])=[C:24]1[C:25]([O:27][CH3:28])=[O:26]

참가 물질

4

반응물 2

HCID 54059666Cyclopentyl 2-(2,3-dichlorophenylmethylene)-3-oxobutanoateHCID 73668923Methyl 3-amino-4-fluoro-2-butenoate

생성물 1

HCID 700905275-Cyclopentyl 3-methyl 4-(2,3-dichlorophenyl)-2-(fluoromethyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

시약·촉매·용매 1

HCID 6386tert-Butanol용매

실험 절차

A solution of the product of step (a) (5.1 g, 14.3 mmoles) and methyl 3-amino-4-fluoro-2-butenoate (1.9 g, 14.3 mmoles) in dry tert-butanol (25 ml) was heated to 60° (oil bath temperature) for 108 hours. The solution was allowed to cool to room temperature and the solvent removed in vacuo. Chromatography on silica eluting with dichloromethane afforded the title compound as a yellow oil which crystallises on addition of petroleum ether (60°-80° ) to afford the title compound 1.5 g mp 148°-9°. (Identical with the product of Example 3).

후처리

  1. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-a018ff87fe284e27a01f07bd10715329
출처 데이터셋
uspto-grants-1987_08
특허 번호
US04686217

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