Ammonia → 1-(2-hydroxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride hydrate

HRID 1789420노트

반응식

HRID 1789420 반응식
C([O:9][CH2:10][CH2:11][N:12]1[C:24]2[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]=[C:16]([Cl:25])[C:15]=2[N:14]=[CH:13]1)(=[O:8])C1C=CC=CC=1.[NH3:26]>CO.Cl>[OH2:8].[ClH:25].[OH:9][CH2:10][CH2:11][N:12]1[C:24]2[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]=[C:16]([NH2:26])[C:15]=2[N:14]=[CH:13]1

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 139584251-(2-benzoyloxyethyl)-4-chloro-1H-imidazo[4,5-c]quinoline

생성물 1

HCID 139828911-(2-hydroxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride hydrate

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매

실험 절차

A mixture of 1.3 g (0.0037 mole) of 1-(2-benzoyloxyethyl)-4-chloro-1H-imidazo[4,5-c]quinoline (from Example 117) in 60 ml of methanol was saturated with about 10g of ammonia gas. The mixture was heated at 150° C. in a steel bomb for ten hours. The mixture was evaporated, and the residue was slurried in diethyl ether and filtered. The solid obtained was slurried in methanolic hydrochloric acid to provide off-white solid 1-(2-hydroxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine hydrochloride hydrate, m.p. >250° C. Analysis: Calculated for C12H12N4O·HCl·1.25H2O: C, 50.2; % H, 5.4; % N, 19.5; Found: % C, 50.2; % H, 5.2; % N, 19.1.

후처리

  1. customThe mixture was evaporated
  2. filtrationfiltered
  3. customThe solid obtained

출처 및 근거

ORD 기록
ord-d55cf3cb02ba41bab50cae8993ff9059
출처 데이터셋
uspto-grants-1987_08
특허 번호
US04689338

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