1-(4-nitrophenethyl)-1H-imidazole → 4-[2-(1H-imidazol-1-yl)ethyl]aniline

HRID 1789478노트

반응식

HRID 1789478 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.Cl.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:6][CH:5]=1

참가 물질

5

반응물 1

HCID 33171661-(4-nitrophenethyl)-1H-imidazole

생성물 1

HCID 35236744-[2-(1H-imidazol-1-yl)ethyl]aniline

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

A solution of 10 g (0.046 mole) of 1-[2-(4-nitrophenyl)ethyl]-1H-imidazole in 100 mL of ethanol, 50 mL of 10% aqueous hydrochloric acid and 1.0 g of 5% Pd/C catalyst are placed in a small Parr bottle and hydrogenated at 50 psi pressure for about 24 hours. Additional H2 is added as needed to maintain 50 psi pressure. The reaction mixture is filtered and the solvent is concentrated in vacuo. The residue is dissolved in 100 mL of water and made basic (pH 9) with potassium carbonate. Extract the aqueous mixture with methylene chloride (2×100 mL) and combine. Evaporation of the solvent yields the title compound.

후처리

  1. additionAdditional H2 is added
  2. temperatureto maintain 50 psi pressure
  3. filtrationThe reaction mixture is filtered
  4. concentrationthe solvent is concentrated in vacuo
  5. dissolutionThe residue is dissolved in 100 mL of water
  6. extractionExtract the aqueous mixture with methylene chloride (2×100 mL)
  7. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-8942f05ad9b44f1aa6ee60dbe5607694
출처 데이터셋
uspto-grants-1987_08
특허 번호
US04689341

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