Methyl iodide → 3-Methyl-1-[2-[4-((methylsulfonyl)amino)phenyl]ethyl]-1H-imidazolium iodide

HRID 1789480노트

반응식

HRID 1789480 반응식
[N:1]1([CH2:6][CH2:7][C:8]2[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[I:19][CH3:20]>CO>[I-:19].[CH3:20][N:3]1[CH:4]=[CH:5][NH+:1]([CH2:6][CH2:7][C:8]2[CH:9]=[CH:10][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:12][CH:13]=2)[CH2:2]1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 137633971-[2-[4-[(Methylsulfonyl)amino]phenyl]ethyl]-1H-imidazole

생성물 1

HCID 704378243-Methyl-1-[2-[4-((methylsulfonyl)amino)phenyl]ethyl]-1H-imidazolium iodide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Heat a mixture of 5 g (0.019 mole) of N-[4-[2-(1H-imidazol-1-yl)ethyl]phenyl]methanesulfonamide, 5 mL of iodomethane and 25 mL of methanol in a pressure tube at 75° C. for about 24 hours. Cool the mixture to room temperature and remove the solvents in vacuo. Slurry the residue in acetone (50 mL) and filter and wash with acetone (100 mL). Drying provides the title compound, which may be recrystallized from methanol.

후처리

  1. temperatureHeat
  2. customremove the solvents in vacuo
  3. filtrationfilter
  4. washwash with acetone (100 mL)
  5. customDrying

출처 및 근거

ORD 기록
ord-fe6bc469579849c190d98ec39f6d6c77
출처 데이터셋
uspto-grants-1987_08
특허 번호
US04689341

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