2-Acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester → 3-(6-Amino-5-methyl-pyridin-3-yl)-2-mercaptomethyl-2-methyl-propionic acid

HRID 1789824노트

반응식

HRID 1789824 반응식
C([O:3][C:4](=[O:21])[C:5]([CH2:16][S:17]C(=O)C)([CH3:15])[CH2:6][C:7]1[CH:8]=[N:9][C:10]([NH2:14])=[C:11]([CH3:13])[CH:12]=1)C>Cl>[NH2:14][C:10]1[N:9]=[CH:8][C:7]([CH2:6][C:5]([CH2:16][SH:17])([CH3:15])[C:4]([OH:21])=[O:3])=[CH:12][C:11]=1[CH3:13]

참가 물질

3

반응물 1

HCID 572012572-Acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester

생성물 1

HCID 101986553-(6-Amino-5-methyl-pyridin-3-yl)-2-mercaptomethyl-2-methyl-propionic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

2-Acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester (17 mg, 40 μmol) was dissolved in conc. HCl (2 mL) under argon. The solution was heated to reflux for 150 min. Concentration under reduced pressure gave the title compound as the hydrochloride salt (10.7 mg, 96%).

후처리

  1. temperatureThe solution was heated
  2. temperatureto reflux for 150 min
  3. concentrationConcentration under reduced pressure

출처 및 근거

ORD 기록
ord-b962369971ea4d278e8a5ef08961e63a
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07071175B1

반응 노트

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