3-Acetylsulfanyl-2-(6-tert-butoxycarbonylamino-pyridin-3-ylmethyl)-butyric acid ethyl ester → 2-(6-Amino-pyridin-3-ylmethyl)-3-mercapto-butyric acid

HRID 1789875노트

반응식

HRID 1789875 반응식
C([O:3][C:4](=[O:27])[CH:5]([CH2:12][C:13]1[CH:14]=[N:15][C:16]([NH:19]C(OC(C)(C)C)=O)=[CH:17][CH:18]=1)[CH:6]([S:8]C(=O)C)[CH3:7])C>Cl>[NH2:19][C:16]1[N:15]=[CH:14][C:13]([CH2:12][CH:5]([CH:6]([SH:8])[CH3:7])[C:4]([OH:27])=[O:3])=[CH:18][CH:17]=1

참가 물질

3

반응물 1

HCID 537302483-Acetylsulfanyl-2-(6-tert-butoxycarbonylamino-pyridin-3-ylmethyl)-butyric acid ethyl ester

생성물 1

HCID 97945372-(6-Amino-pyridin-3-ylmethyl)-3-mercapto-butyric acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 3-acetylsulfanyl-2-(6-tert-butoxycarbonylamino-pyridin-3-ylmethyl)-butyric acid ethyl ester/B (55 mg; 0.14 mmol) in concentrated HCl (2 mL) was refluxed under argon for 1 hour. The reaction mixture was allowed to cool to room temperature and concentrated under reduced pressure to afford 39.4 mg of the title compound as the hydrochloride salt.

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-0294f9f994f74d49b5d1528e5d08120d
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07071175B1

반응 노트

불러오는 중…