2-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-3-phenyl-propionic acid ethyl ester → 3-(6-Amino-pyridin-3-yl)-2-mercaptomethyl-3-phenyl-propionic acid

HRID 1789915노트

반응식

HRID 1789915 반응식
C([O:3][C:4](=[O:32])[CH:5]([CH2:27][S:28]C(=O)C)[CH:6]([C:13]1[CH:14]=[N:15][C:16]([NH:19]C(OC(C)(C)C)=O)=[CH:17][CH:18]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C>Cl>[NH2:19][C:16]1[N:15]=[CH:14][C:13]([CH:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:5]([CH2:27][SH:28])[C:4]([OH:32])=[O:3])=[CH:18][CH:17]=1

참가 물질

3

반응물 1

HCID 539704052-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-3-phenyl-propionic acid ethyl ester

생성물 1

HCID 220361473-(6-Amino-pyridin-3-yl)-2-mercaptomethyl-3-phenyl-propionic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

2-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl )-3-phenyl-propionic acid ethyl ester (58 mg, 0.125 mmol) was dissolved in conc. HCl (3.0 mL). The solution was heated to reflux for 130 min under argon. Concentration under reduced pressure gave the title compound as the hydrochloride salt (41 mg, 100%).

후처리

  1. temperatureThe solution was heated
  2. temperatureto reflux for 130 min under argon
  3. concentrationConcentration under reduced pressure

출처 및 근거

ORD 기록
ord-17582d8f0b60422395c84343561351ad
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07071175B1

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