1-[1-(4-Fluorophenethyl)-piperidin-4-yl]-6-(cyclopropylcarbamoylmethyl)indoline → 1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-(ethylcarbamoylmethyl)indole

HRID 1790500노트

반응식

HRID 1790500 반응식
[F:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][C:24](=[O:29])[NH:25][CH:26]5C[CH2:27]5)[CH:21]=4)[CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][N:8]2[CH2:9][CH2:10][CH:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][C:24](=[O:29])[NH:25][CH2:26][CH3:27])[CH:21]=4)[CH:16]=[CH:15]3)[CH2:12][CH2:13]2)=[CH:30][CH:31]=1

참가 물질

4

반응물 1

HCID 220378941-[1-(4-Fluorophenethyl)-piperidin-4-yl]-6-(cyclopropylcarbamoylmethyl)indoline

생성물 1

HCID 220383791-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-(ethylcarbamoylmethyl)indole수율 81.9%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

반응 조건

온도
50 °C

실험 절차

A suspension of 1-[1-(4-fluorophenethyl)piperidin-4-yl]-6-[(cyclopropylcarbamoyl)methyl]indoline (0.04 g) obtained in Example 154 and active manganese dioxide (0.04 g) in chloroform (30 ml) was vigorously stirred at 50° C. for 10 hr. Then the reaction mixtures were filtered through celite and the residue was washed with chloroform. After concentrating the filtrate under reduced pressure, the residue was recrystallized from chloroform/hexane to give the title compound (0.03 g) as a white powder (yield: 81.9%).

후처리

  1. customThen the reaction mixtures
  2. filtrationwere filtered through celite
  3. washthe residue was washed with chloroform
  4. concentrationAfter concentrating the filtrate under reduced pressure
  5. customthe residue was recrystallized from chloroform/hexane

출처 및 근거

ORD 기록
ord-16fb0e97fa884abab3ac689844bcc368
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07071201B2

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