1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-[(isobutylcarbamoyl)methyl]indoline → 1-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-(ethylcarbamoylmethyl)indole

HRID 1790501노트

반응식

HRID 1790501 반응식
[F:1][C:2]1[CH:32]=[CH:31][C:5]([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][CH:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][C:24](=[O:30])[NH:25][CH2:26][CH:27](C)C)[CH:21]=4)[CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][N:8]2[CH2:9][CH2:10][CH:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][C:24](=[O:30])[NH:25][CH2:26][CH3:27])[CH:21]=4)[CH:16]=[CH:15]3)[CH2:12][CH2:13]2)=[CH:31][CH:32]=1

참가 물질

4

반응물 1

HCID 220379731-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-[(isobutylcarbamoyl)methyl]indoline

생성물 1

HCID 220383791-[1-(4-Fluorophenethyl)piperidin-4-yl]-6-(ethylcarbamoylmethyl)indole수율 76.7%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

반응 조건

온도
50 °C

실험 절차

A suspension of 1-[1-(4-fluorophenethyl)piperidin-4-yl]-6-[(isobutylcarbamoyl)methyl]indoline (0.07 g) obtained in Example 152 and active manganese dioxide (0.07 g) in chloroform (30 ml) was vigorously stirred at 50° C. overnight. Then the reaction mixtures were filtered through celite and the residue was washed with chloroform. After concentrating the filtrate under reduced pressure, the residue was recrystallized from chloroform/hexane to give the title compound (0.05 g) as a white powder (yield: 70.0%).

후처리

  1. customThen the reaction mixtures
  2. filtrationwere filtered through celite
  3. washthe residue was washed with chloroform
  4. concentrationAfter concentrating the filtrate under reduced pressure
  5. customthe residue was recrystallized from chloroform/hexane

출처 및 근거

ORD 기록
ord-7ba06a0745eb45d59643d5c89d39e192
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07071201B2

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