Tetrahydrofuran → 7-(2-Fluoro-4-iodo-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid

반응식

[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[CH3:25][Si:26]([N-:27][Si:28]([CH3:29])([CH3:30])[CH3:31])([CH3:32])[CH3:33].[Cl:1][c:2]1[cH:3][c:4](=[O:14])[n:5]2[c:9]([c:10]1[C:11](=[O:12])[OH:13])[CH2:8][CH2:7][CH2:6]2.[F:15][c:16]1[c:17]([NH2:18])[cH:19][cH:20][c:21]([I:23])[cH:22]1.[Li+:24]>>[c:2]1([NH:18][c:17]2[c:16]([F:15])[cH:22][c:21]([I:23])[cH:20][cH:19]2)[cH:3][c:4](=[O:14])[n:5]2[c:9]([c:10]1[C:11](=[O:12])[OH:13])[CH2:8][CH2:7][CH2:6]2