Sodium Chloride → HCID 22042477, 화합물

HRID 1790886노트

반응식

HRID 1790886 반응식
[Cl-].[Li+].COP([CH2:9][CH2:10][CH:11]=[O:12])(=O)OC.[CH:13](N(C(C)C)CC)(C)C.[CH3:22][C:23]1([C:28]2(C=O)[CH2:30][CH2:29]2)[O:27][CH2:26][CH2:25][O:24]1.[Cl-].[Na+]>C(#N)C>[CH3:22][C:23]1([C:28]2(/[CH:9]=[CH:10]/[C:11](=[O:12])[CH3:13])[CH2:30][CH2:29]2)[O:27][CH2:26][CH2:25][O:24]1

참가 물질

7

반응물 5

HCID 5234Sodium ChlorideHCID 81531DiisopropylethylamineHCID 433294Lithium ChlorideHCID 11147922oxopropylphosphonic acid dimethyl esterHCID 143755571-(2-Methyl-1,3-dioxolan-2-YL)cyclopropane-1-carbaldehyde

생성물 1

HCID 22042477HCID 22042477, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

13.8 g of lithium chloride (anhydrous) is introduced into 120 ml of acetonitrile under nitrogen, and 49.8 ml of oxopropylphosphonic acid dimethyl ester, 51.3 ml of diisopropylethylamine and 5.4 g of aldehyde 7 are added in succession. It is stirred for 18 hours at room temperature, and then sodium chloride solution is added. It is extracted with ethyl acetate, washed with sodium chloride solution and dried on sodium sulfate. The residue is chromatographed on silica gel with ethyl acetate/hexane, whereby 5.3 g of the title compound accumulates as a colorless oil.

후처리

  1. extractionIt is extracted with ethyl acetate
  2. washwashed with sodium chloride solution
  3. customdried on sodium sulfate
  4. customThe residue is chromatographed on silica gel with ethyl acetate/hexane, whereby 5.3 g of the title compound accumulates as a colorless oil

출처 및 근거

ORD 기록
ord-f5acf844c5c24b999fc9ae28f72b4c88
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07071344B1

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