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Pyridine → HCID 178517747, 화합물

HRID 1791261
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HRID 1791261 반응식
[NH2:1][C:2]1[CH:10]=[C:9]([C:11]2[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:14]=[CH:13][N:12]=2)[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].N1C=CC=CC=1.[CH2:27]([O:34][CH2:35][CH2:36][CH2:37][C:38](Cl)=O)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.[OH-].[Na+]>C1COCC1>[CH2:27]([O:34][CH2:35][CH2:36][CH2:37][C:38]1[N:6]=[C:4]([OH:5])[C:3]2[C:2](=[CH:10][C:9]([C:11]3[C:16]([C:17]([F:20])([F:18])[F:19])=[CH:15][CH:14]=[CH:13][N:12]=3)=[CH:8][CH:7]=2)[N:1]=1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 1049PyridineHCID 14798Sodium HydroxideHCID 220300742-Amino4-(3-trifluoromethyl-pyridin-2-yl)-benzamideHCID 220305014-(Benzyloxy)butanoyl chloride

생성물 1

HCID 178517747HCID 178517747, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-amino-4-(3-trifluoromethyl-pyridin-2-yl)-benzamide (3.56 mmol) and pyridine (3.91 mmol) in THF (20 ml) add 4-benzyloxy-butyryl chloride (3.91 mmol). Stir the mixture 20 minutes at room temperature, add 20 ml of 20% NaOH, stir for 60 minutes at 50° C. Concentrate, add water, filter, acidify to pH=6, collect the precipitate to obtain 2-(3-benzyloxy-propyl)-7-(3-trifluoromethyl-pyridin-2-yl)-quinazolin-4-ol.

후처리

  1. stirringstir for 60 minutes at 50° C
  2. concentrationConcentrate
  3. additionadd water
  4. filtrationfilter
  5. customcollect the precipitate

출처 및 근거

ORD 기록
ord-76f21bcd99754d0cb5b8bcefa0ae7101
출처 데이터셋
uspto-grants-2006_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07074799B2

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