Hydrochloric Acid → 7-Benzyloxy-4(indol-5-ylamino)-6-methoxyquinazoline hydrochloride

HRID 1791722노트

반응식

HRID 1791722 반응식
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([Cl:19])=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:22][C:23]1[CH:24]=[C:25]2[C:29](=[CH:30][CH:31]=1)[NH:28][CH:27]=[CH:26]2.Cl>C(O)(C)C>[ClH:19].[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([NH:22][C:23]3[CH:24]=[C:25]4[C:29](=[CH:30][CH:31]=3)[NH:28][CH:27]=[CH:26]4)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 788675-AminoindoleHCID 106619987-(Benzyloxy)-4-chloro-6-methoxyquinazoline

생성물 1

HCID 220305477-Benzyloxy-4(indol-5-ylamino)-6-methoxyquinazoline hydrochloride수율 96%

시약·촉매·용매 1

HCID 3776Isopropanol용매2회

실험 절차

A solution of 7-benzyloxy-4-chloro-6-methoxyquinazoline (5 g, 16.6 mmol), (prepared as described for the starting material in Example 1), 5-aminoindole (2.4 g, 18.2 mmol) in isopropanol (60 ml) containing 5N hydrogen chloride in isopropanol (260 μl, 1.6 mmol) was refluxed for 90 minutes. After cooling the volatiles were removed under vacuum. The solid was triturated with isopropanol, filtered, washed with isopropanol followed by ether and dried under vacuum to give 7-benzyloxy-4(indol-5-ylamino)-6-methoxyquinazoline hydrochloride (6.9 g, 96%).

후처리

  1. temperaturewas refluxed for 90 minutes
  2. temperatureAfter cooling the volatiles
  3. customwere removed under vacuum
  4. customThe solid was triturated with isopropanol
  5. filtrationfiltered
  6. washwashed with isopropanol
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-01d532ea73d146a0826d5a2a83c5d8b3
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07074800B1

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