Sodium Hydroxide → 3-((Pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one

HRID 1791735노트

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HRID 1791735 반응식
Cl.CO[C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1OCC1CCNCC1)[N:10]=[CH:9][N:8]([CH2:22][O:23][C:24](=[O:29])[C:25]([CH3:28])([CH3:27])[CH3:26])[C:7]2=[O:30].[OH-].[Na+]>O>[C:24]([O:23][CH2:22][N:8]1[C:7](=[O:30])[C:6]2[C:11](=[CH:12][CH:13]=[CH:4][CH:5]=2)[N:10]=[CH:9]1)(=[O:29])[C:25]([CH3:28])([CH3:27])[CH3:26]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 220306726-Methoxy-7-((piperidin-4-yl)methoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one hydrochloride

생성물 1

HCID 206891733-((Pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one수율 132.6%

시약·촉매·용매 1

HCID 962Water용매

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온도
0 °C

실험 절차

To a suspension of 6-methoxy-7-(piperidin-4-ylmethoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one hydrochloride (34 g, 84 mmol), (prepared as described for the starting material in Example 12), in water cooled at 0° C. was added 1N sodium hydroxide until the mixture was at pH8. The solution was extracted with trichloromethane and the organic layer was dried (MgSO4), filtered and evaporated to give 6-methoxy-7-piperidin-4-ylmethoxy)-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (29 g).

후처리

  1. custom(prepared
  2. extractionThe solution was extracted with trichloromethane
  3. dry with materialthe organic layer was dried (MgSO4)
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-1fedcee2041d4060b14263b35a021e3b
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07074800B1

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