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tert-Butyl piperazine-1-carboxylate → HCID 23536931, 화합물

HRID 1792081
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인쇄 미리보기

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HRID 1792081 반응식
Cl[C:2]1[N:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH:17]=[O:18])[C:9]2[C:8](=[O:19])[N:7]([CH2:20][O:21][C:22](=[O:27])[C:23]([CH3:26])([CH3:25])[CH3:24])[C:6](=[O:28])[N:5]([CH2:29][O:30][C:31](=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33])[C:4]=2[N:3]=1.[C:37]([O:41][C:42]([N:44]1[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]1)=[O:43])([CH3:40])([CH3:39])[CH3:38]>C(Cl)(Cl)Cl>[C:37]([O:41][C:42]([N:44]1[CH2:49][CH2:48][N:47]([C:2]2[N:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[CH:17]=[O:18])[C:9]3[C:8](=[O:19])[N:7]([CH2:20][O:21][C:22](=[O:27])[C:23]([CH3:24])([CH3:26])[CH3:25])[C:6](=[O:28])[N:5]([CH2:29][O:30][C:31](=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33])[C:4]=3[N:3]=2)[CH2:46][CH2:45]1)=[O:43])([CH3:40])([CH3:38])[CH3:39]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 235368902,2-Dimethylpropionic acid [8-chloro-1-(2,2-dimethyl-propionyloxymethyl)-7-(2-formylphenyl)-2,6-dioxo-1,2,6,7-tetrahydropurin-3-yl]methyl ester

생성물 1

HCID 23536931HCID 23536931, 화합물수율 75.3%

시약·촉매·용매 1

HCID 6212Chloroform용매

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온도
150 °C

실험 절차

2,2-Dimethylpropionic acid [8-chloro-1-(2,2-dimethyl-propionyloxymethyl)-7-(2-formylphenyl)-2,6-dioxo-1,2,6,7-tetrahydropurin-3-yl]methyl ester (2.0 g) and piperazine-1-carboxylic acid tert-butyl ester (2.15 g) were mixed, and the mixture was stirred at 150° C. for 1 hour and 10 minutes. The reaction mixture was diluted with chloroform and purified by silica gel column chromatography to give 1.94 g of the title compound from the elution fraction of hexane-ethyl acetate (1:1).

후처리

  1. custompurified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-15d6af6873dd481bba186ab0b176bf15
출처 데이터셋
uspto-grants-2006_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07074798B2

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