Hydrazine hydrate (1:1) → 6-Bromoquinazoline-4-carboxylic acid hydrazide

HRID 1792500노트

반응식

HRID 1792500 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[C:12]([O:14]C)=O.O.[NH2:17][NH2:18]>CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[C:12]([NH:17][NH2:18])=[O:14]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 22031300Methyl 6-bromoquinazoline-4-carboxylate

생성물 1

HCID 235376576-Bromoquinazoline-4-carboxylic acid hydrazide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 961 mg methyl 6-bromoquinazoline-4-carboxylate (compound in Production Example 413), 0.9 mL hydrazine monohydrate and 70 mL methanol was stirred at room temperature for 30 minutes, and the precipitated crystals were collected by filtration. The filtrate was evaporated to give additional crystals. The title compound, 838 mg in total, was obtained as pale yellow crystals.

후처리

  1. filtrationthe precipitated crystals were collected by filtration
  2. customThe filtrate was evaporated
  3. customto give additional crystals

출처 및 근거

ORD 기록
ord-b96e73a1e56e4329afd9d3fefcac5524
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07074801B1

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