Sulfanilamide → HCID 178512579, 화합물

HRID 1792770

반응식

HRID 1792770 반응식
[S:1]([NH2:11])(=[O:10])([C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1)=[O:2].C([NH:20][C:21]#[N:22])(=O)C1C=CC=CC=1>C(O)C.Cl>[S:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:21]([NH2:22])=[NH:20])=[CH:7][CH:8]=1)(=[O:10])(=[O:2])[NH2:11]

참가 물질

5

반응물 2

HCID 5333SulfanilamideHCID 84805Benzamide, N-cyano-

생성물 1

HCID 178512579HCID 178512579, 화합물

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

A mixture of sulphanilamide (20 g, 0.166 mol), benzoyl cyanamide (34 g, 0.33 mol) in ethanol (60 ml) and concentrated hydrochloric acid (11 ml) was heated on a steam bath until the solvent had evaporated. Water was added and the mixture heated at reflux for 5 minutes. Sodium hydroxide (14.4 g) was added and the mixture heated at reflux. The mixture was allowed to cool and was adjusted to pH2 with hydrochloric acid and the precipitated solid removed by filtration. The filtrate was neutralised and the solvent removed by evaporation. The residue was recrystallized from water to give the crude title product. m/z: 215 [MH]+.

후처리

  1. temperaturewas heated on a steam bath until the solvent
  2. customhad evaporated
  3. additionWater was added
  4. temperaturethe mixture heated
  5. temperatureat reflux for 5 minutes
  6. additionSodium hydroxide (14.4 g) was added
  7. temperaturethe mixture heated
  8. temperatureat reflux
  9. temperatureto cool
  10. customthe precipitated solid removed by filtration
  11. customthe solvent removed by evaporation
  12. customThe residue was recrystallized from water

출처 및 근거

ORD 기록
ord-e5c80abd908e434e87362660a829fe62
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07078410B2

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