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Water → Methyl 1-(quinolin-2-yl)-1H-pyrrole-3-carboxylate

HRID 1792784
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HRID 1792784 반응식
C(=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][C:9]([C:11]1[CH:15]=[CH:14][NH:13][CH:12]=1)=[O:10].Cl[C:17]1[CH:26]=[CH:25][C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1.O>CS(C)=O>[CH3:7][O:8][C:9]([C:11]1[CH:15]=[CH:14][N:13]([C:17]2[CH:26]=[CH:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]=2)[CH:12]=1)=[O:10]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 119282-ChloroquinolineHCID 12361759methyl 1H-pyrrole-3-carboxylate

생성물 1

HCID 22024968Methyl 1-(quinolin-2-yl)-1H-pyrrole-3-carboxylate수율 65.8%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide
용매

반응 조건

온도
100 °C

실험 절차

1.73 g (12.5 mmol) of potassium carbonate are added at 20° C. under an argon atmosphere to 0.625 g (5 mmol) of 3-methoxycarbonyl-1H-pyrrole and 0.82 g (5 mmol) of 2-chloroquinoline dissolved in 10 mL of dimethyl sulphoxide. After stirring at 100° C. for 23 hours, the reaction mixture is poured into 30 mL of water and is then allowed to crystallise at 20° C. for 1 hour. After filtering off and air-drying the solid residue, 0.83 g of 3-methoxycarbonyl-1-(quinol-2-yl)-1H-pyrrole is obtained in the form of a beige-coloured solid melting at 136° C.

후처리

  1. customto crystallise at 20° C. for 1 hour
  2. filtrationAfter filtering off
  3. customair-drying the solid residue

출처 및 근거

ORD 기록
ord-94ad8cdeae8d45b6af653a0441258466
출처 데이터셋
uspto-grants-2006_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07078414B2

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