Sodium Hydroxide → 1-Butanol, 2-(4-pyrimidinylamino)-

HRID 1793083노트

반응식

HRID 1793083 반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]([CH2:12][CH3:13])[CH2:10][OH:11])[CH:3]=1.[OH-].[Na+]>C(O)C.[Pd]>[N:7]1[CH:2]=[CH:3][C:4]([NH:8][CH:9]([CH2:12][CH3:13])[CH2:10][OH:11])=[N:5][CH:6]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 22024413HCID 22024413, 화합물

생성물 1

HCID 220243971-Butanol, 2-(4-pyrimidinylamino)-

시약·촉매·용매 2

HCID 23938Palladium촉매2회HCID 702Ethanol용매

실험 절차

2-[(6-Chloro-4-pyrimidinyl)amino]-1-butanol was dissolved in ethanol (110 mL), which was sequentially added with a 5N aqueous sodium hydroxide solution (5.5 mL) and Pd—C (hydrous product; 0.55 g), and hydrogenation was performed under hydrogen atmosphere at a normal temperature and a normal pressure. After completion of the reaction, Pd—C was filtered off, and the solvent was evaporated. The resulting residue was extracted with dichloromethane-methanol, and the solvent was removed to give the title compound (4.3 g) as white crystals.

후처리

  1. filtrationwas filtered off
  2. customthe solvent was evaporated
  3. extractionThe resulting residue was extracted with dichloromethane-methanol
  4. customthe solvent was removed

출처 및 근거

ORD 기록
ord-7aeaa9b5e887432ea2aa67e82af68d84
출처 데이터셋
uspto-grants-2006_07
특허 번호
US07078405B2

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