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Hydrochloric Acid → 3-[6-(4-Acetyl-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-4-chloro-1H-pyridin-2-one

HRID 1793712
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HRID 1793712 반응식
I[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([O:8]C)[C:3]=1[C:10]1[NH:11][C:12]2[CH:18]=[C:17]([N:19]3[CH2:24][CH2:23][N:22]([C:25](=[O:27])[CH3:26])[CH2:21][CH2:20]3)[CH:16]=[C:15]([CH3:28])[C:13]=2[N:14]=1.O.[ClH:30]>O1CCOCC1>[C:25]([N:22]1[CH2:23][CH2:24][N:19]([C:17]2[CH:16]=[C:15]([CH3:28])[C:13]3[N:14]=[C:10]([C:3]4[C:4](=[O:8])[NH:5][CH:6]=[CH:7][C:2]=4[Cl:30])[NH:11][C:12]=3[CH:18]=2)[CH2:20][CH2:21]1)(=[O:27])[CH3:26]
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 220213071-{4-[2-(4-Iodo-2-methoxy-pyridin-3-yl)-7-methyl-3H-benzimidazol-5-yl]-piperazin-1-yl}-ethanone

생성물 1

HCID 1356816973-[6-(4-Acetyl-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-4-chloro-1H-pyridin-2-one수율 100%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of 1-{4-[2-(4-Iodo-2-methoxy-pyridin-3-yl)-7-methyl-3H-benzimidazol-5-yl]-piperazin-1-yl}-ethanone (5.2 g, 10.6 mmol) in 4 M HCl in dioxane (60 mL) was added water (5 mL). The reaction mixture was stirred at room temperature for 14 h. Concentration of the reaction mixture gave the title compound (4.02 g, 100%) which was used for the next step without purification. LCMS (M+H)+ m/z 486 (t=1.55 min.).

출처 및 근거

ORD 기록
ord-93c4cc724c774189a107cfeb372b15b6
출처 데이터셋
uspto-grants-2006_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07081454B2

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