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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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2-Amino-1-butanol, (-)- → 3-{4-[6-(1-Hydroxymethyl-propylamino)-2-oxo-3-propyl-3,7-dihydro2H-purin-8-yl]-bicyclo[2.2.2]oct-1-yl]-propionic acid methyl ester

HRID 1793821
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인쇄 미리보기

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HRID 1793821 반응식
[CH3:1][O:2][C:3](=[O:29])[CH2:4][CH2:5][C:6]12[CH2:13][CH2:12][C:9]([C:14]3[NH:22][C:21]4[C:20](SC)=[N:19][C:18](=[O:25])[N:17]([CH2:26][CH2:27][CH3:28])[C:16]=4[N:15]=3)([CH2:10][CH2:11]1)[CH2:8][CH2:7]2.[NH2:30][C@H:31]([CH2:34][CH3:35])[CH2:32][OH:33]>CS(C)=O>[CH3:1][O:2][C:3](=[O:29])[CH2:4][CH2:5][C:6]12[CH2:13][CH2:12][C:9]([C:14]3[NH:22][C:21]4[C:20]([NH:30][CH:31]([CH2:32][OH:33])[CH2:34][CH3:35])=[N:19][C:18](=[O:25])[N:17]([CH2:26][CH2:27][CH3:28])[C:16]=4[N:15]=3)([CH2:10][CH2:11]1)[CH2:8][CH2:7]2
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참가 물질

4

반응물 2

HCID 27238562-Amino-1-butanol, (-)-2회HCID 119944193-[4-(6-Methylsulfanyl-2-oxo-3-propyl-3,7-dihydro-2H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-propionic acid methyl ester

생성물 1

HCID 691473133-{4-[6-(1-Hydroxymethyl-propylamino)-2-oxo-3-propyl-3,7-dihydro2H-purin-8-yl]-bicyclo[2.2.2]oct-1-yl]-propionic acid methyl ester

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

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온도
150 °C

실험 절차

3-[4-(6-Methylsulfanyl-2-oxo-3-propyl-3,7-dihydro-2H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-propionic acid methyl ester (105 mg) was dissolved in 2 mL of DMSO along with an appropriate amino alcohol (e.g., 160 uL of (R)-2-amino-1-butanol for compound 3). The reaction mixture was stirred at 150° C. for 3 h. It was then cooled to rt and purified by preparative HPLC to afford 50 mg of the titled compound.

후처리

  1. temperatureIt was then cooled to rt
  2. custompurified by preparative HPLC

출처 및 근거

ORD 기록
ord-1e7398f86ebd47c2b797ef9a88162610
출처 데이터셋
uspto-grants-2006_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07022686B2

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