Hydrochloric Acid → HCID 10474189, 화합물

HRID 1793823노트

반응식

HRID 1793823 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]([C:13]2[CH:18]=[C:17]([OH:19])[C:16]([O:20][CH3:21])=[CH:15][C:14]=2[CH:22]([CH2:26][CH3:27])[C:23](=O)[CH3:24])=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[NH2:28][NH2:29].Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:13]3[CH:18]=[C:17]([OH:19])[C:16]([O:20][CH3:21])=[CH:15][C:14]=3[CH:22]([CH2:26][CH3:27])[C:23]([CH3:24])=[N:29][N:28]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 9321HydrazineHCID 222197323-[2-(3,4-Dimethoxybenzoyl)-4-hydroxy-5-methoxyphenyl]pentan-2-one

생성물 1

HCID 10474189HCID 10474189, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 14 g of 3-{2-[(3,4-dimethoxyphenyl)carbonyl]-4-hydroxy-5-methoxyphenyl}pentan-2-one and 4.7 mL of hydrazine in 280 mL of ethanol was heated at reflux for 0.5 hr. After allowing the solution to cool to room temperature, it was saturated with HCl gas. The mixture was then concentrated to a volume of about 5 mL, basified with concentrated ammonium hydroxide, and extracted with methylene chloride. The combined methylene chloride extracts were dried and concentrated, and the residue recrystallized from ethyl acetate/hexane. Yield: 1.5 g

후처리

  1. temperatureat reflux for 0.5 hr
  2. concentrationThe mixture was then concentrated to a volume of about 5 mL
  3. extractionextracted with methylene chloride
  4. dry with materialThe combined methylene chloride extracts were dried
  5. concentrationconcentrated
  6. customthe residue recrystallized from ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-cf908bae29b7404681d8111d8162a2a9
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07022700B2

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