홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Carbonate → [(6-Fluoropyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile

HRID 1795138
노트
인쇄 미리보기

반응식

HRID 1795138 반응식
[F:1][C:2]([F:11])([F:10])[CH2:3][CH2:4][CH:5]([C:8]#[N:9])[C:6]#[N:7].C(=O)([O-])[O-].[K+].[K+].[F:18][C:19]1[N:24]=[CH:23][C:22]([CH2:25]Br)=[CH:21][CH:20]=1>CS(C)=O>[F:18][C:19]1[N:24]=[CH:23][C:22]([CH2:25][C:5]([CH2:4][CH2:3][C:2]([F:10])([F:11])[F:1])([C:8]#[N:9])[C:6]#[N:7])=[CH:21][CH:20]=1
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 220506385-(Bromomethyl)-2-fluoropyridineHCID 221857612-(3,3,3-Trifluoropropyl)malononitrile

생성물 1

HCID 22185764[(6-Fluoropyridin-3-yl)methyl](3,3,3-trifluoropropyl)propanedinitrile수율 34.5%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

이 페이지에서참가 물질실험 절차출처 및 근거반응 노트

By using (3,3,3-trifluoropropyl)malononitrile (5.8 g), dimethylsulfoxide (20 ml), potassium carbonate (4.8 g) and 6-fluoro-3-(bromomethyl)pyridine (6.7 g) according to the similar method described in Production Example 4 was obtained 3.3 g of 2-((6-fluoro-3-pyridyl)methyl)-2-(3,3,3-trifluoropropyl)malononitrile represented by the following formula (hereinafter referred to as the present invention compound (13)).

출처 및 근거

ORD 기록
ord-1b3341647f504b419935353504dafd51
출처 데이터셋
uspto-grants-2006_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07026340B2

반응 노트

불러오는 중…