Ammonia → 2-(1-Tetrazolyl)benzylamine

HRID 1795263노트

반응식

HRID 1795263 반응식
[N:1]1([C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[C:8]#[N:9])[CH:5]=[N:4][N:3]=[N:2]1.N>C(O)C.[Ni]>[N:1]1([C:6]2[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=2[CH2:8][NH2:9])[CH:5]=[N:4][N:3]=[N:2]1

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 218662732-(1H-Tetrazol-1-YL)benzonitrile

생성물 1

HCID 111596142-(1-Tetrazolyl)benzylamine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

A solution of 2-tetrazol-1-yl-benzonitrile (1.3 g, 7.6 mmol) in ethanol saturated with ammonia (125 ml) was stirred in the presence of Raney nickel (50% slurry in water, washed with ethanol, catalytic amount) under a hydrogen atmosphere overnight. The reaction mixture was filtered over celite and concentrated to give 2-tetrazol-1-yl-benzylamine; 1H NMR (CDCl3, 400 MHz) δ 9.28 (s, 1H), 7.59 (m, 2H), 7.47 (m, 2H), 3.70 (s, 2H).

후처리

  1. filtrationThe reaction mixture was filtered over celite and
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d2b95d9dace2415cbd4d04ffe1e06d37
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07026324B2

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