Water → 8-(Difluoromethyl)quinoline-5-carboxylic acid

HRID 1795747노트

반응식

HRID 1795747 반응식
[F:1][CH:2]([F:17])[C:3]1[C:12]2[N:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:6]([C:13]([O:15]C)=[O:14])=[CH:5][CH:4]=1.[OH-].[Na+].O>C(O)C>[F:17][CH:2]([F:1])[C:3]1[C:12]2[N:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:6]([C:13]([OH:15])=[O:14])=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 22179174Methyl 8-difluoromethyl-5-quinolinecarboxylate

생성물 1

HCID 221791868-(Difluoromethyl)quinoline-5-carboxylic acid수율 112%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
25 °C

실험 절차

0.5 g (2.0 mmol) of methyl 8-difluoromethyl-5-quinolinecarboxylate was dissolved in 5 ml of ethanol, 0.43 g (10.5 mmol) of sodium hydroxide and 1 ml of water were added, and the mixture was stirred at 25° C. for 20 hours. The solvents were subsequently removed, the residue was taken up in water, washed twice with methylene chloride and adjusted to pH 1 using 10 N hydrochloric acid, and the precipitate was filtered off with suction. Drying gave 0.5 g of 8-difluoromethyl-5-quinolinecarboxylic acid (colorless crystals);

후처리

  1. customThe solvents were subsequently removed
  2. washwashed twice with methylene chloride
  3. filtrationthe precipitate was filtered off with suction
  4. customDrying

출처 및 근거

ORD 기록
ord-daca5a902b094c5cb160bdc9bd25377e
출처 데이터셋
uspto-grants-2006_04
특허 번호
US07030063B1

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