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Dichloromethane → 5,6-Dimethoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile

HRID 1796639
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HRID 1796639 반응식
[OH:1][C:2]1[C:3]([O:27][CH3:28])=[C:4]2[C:9]([NH:10][C:11]3[CH:16]=[CH:15][C:14]([O:17][C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[CH:13][CH:12]=3)=[C:8]([C:24]#[N:25])[CH:7]=[N:6][N:5]2[CH:26]=1.S(OC)(O[CH3:33])(=O)=O.C([O-])([O-])=O.[K+].[K+].C(Cl)Cl>CC(C)=O>[CH3:28][O:27][C:3]1[C:2]([O:1][CH3:33])=[CH:26][N:5]2[C:4]=1[C:9]([NH:10][C:11]1[CH:12]=[CH:13][C:14]([O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:15][CH:16]=1)=[C:8]([C:24]#[N:25])[CH:7]=[N:6]2
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참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 221796556-Hydroxy-5-methoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile

생성물 1

HCID 221796025,6-Dimethoxy-4-(4-phenoxy-phenylamino)-pyrrolo[1,2-b]pyridazine-3-carbonitrile수율 88.5%

시약·촉매·용매 1

HCID 180
Acetone
용매

실험 절차

A mixture of compound from Example 399 (14 mg, 0.038 mmol), dimethyl sulfate (4 μl, 0.042 mmol), K2CO3 (14 mg, 0.101 mmol) in acetone (0.5 ml) was stirred at rt overnight. After regular workup, the title compound (13 mg, 88%) was obtained after silica gel flash column chromatography (100% CH2Cl2). LCMS Found: (M+H)+=387.1

출처 및 근거

ORD 기록
ord-6c8d19d4128445d29015e5c3110982b9
출처 데이터셋
uspto-grants-2006_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07030112B2

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